Who are we?

The central aim of CVON is to improve the national and international position of cardiovascular research in the Netherlands, by supporting large and strong research themes. The ARENA project, an acronym for “Approaching Heart Failure By Translational Research of RNA Mechanisms”, is a collaboration between talented research groups in clinical and basic research across the country.

Our objectives
The collaboration

Welcome to CVON ARENA

Recent advances in the field of microRNAs provide novel possibilities that are on the brink of clinical application. The surprising stability of circulating microRNAs has opened the possibility to develop next generation biomarkers. Inhibition of selected microRNAs is powerful and holds great promise to become the next generation therapeutics. Since microRNAs and their targets are genomically encoded, genetic principles apply and create 'microRNA genetics' as a source of individual variation. CVON, a mutual initiative of the NHS, KNAW, ZonMW and NFU, aims to improve the national and international position of cardiovascular research in the Netherlands, by supporting large and strong research themes.

The ARENA project, an acronym for “Approaching Heart Failure By Translational Research of RNA Mechanisms”, is a collaboration between principal investigators (PI’s) of five University Medical Centers in the Netherlands. ARENA aims to mine the wealth of these ncRNA mechanisms to enable the development of next generation RNA based diagnostics and therapeutics. Each work package is based on recently generated data within the consortium to provide necessary proof of concept. ARENA is expected to address the clinical added value of newly identified RNA based mechanisms and to use the unique models combined in ARENA to mine the wealth of ncRNAs in Heart Failure.


Read about CVON in Pubmed                                                                                                            Read about our CVON ARENA award